Angiotensin and chemoreceptor function

Project Details

Whilst there was some information suggesting angiotensin might play a role in autonomic changes produced by hypoxia, a direct effect on the sensory organ, the carotid body, had not been examined. I demonstrated that the carotid body contains a very high density of angiotensin AT1 receptors and that these are localized on the principal chemoreceptor cells. In addition, I demonstrated that, independent of local blood flow changes, angiotensin excites these cells to increase chemoreceptor afferent activity (Allen, A.M: Angiotensin AT 1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity. J Physiology 1998; 510: 773-782).

Research Group

Allen laboratory: Central cardiovascular regulation



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology