Angiotensin and chemoreceptor function

Project Details

Whilst there was some information suggesting angiotensin might play a role in autonomic changes produced by hypoxia, a direct effect on the sensory organ, the carotid body, had not been examined. I demonstrated that the carotid body contains a very high density of angiotensin AT1 receptors and that these are localized on the principal chemoreceptor cells. In addition, I demonstrated that, independent of local blood flow changes, angiotensin excites these cells to increase chemoreceptor afferent activity (Allen, A.M: Angiotensin AT 1 receptor-mediated excitation of rat carotid body chemoreceptor afferent activity. J Physiology 1998; 510: 773-782).

Research Group

Allen laboratory: Central cardiovascular regulation



Faculty Research Themes

Neuroscience

School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology

Unit / Centre

Allen laboratory: Central cardiovascular regulation