Understanding the cellular cues that direct muscle stem cell specification

Project Details

One of the most important and unresolved issues in skeletal muscle biology is understanding the role of muscle stem cells in the regulation of growth and development, adaptation and plasticity. We have identified that the local skeletal muscle metabolic milieu may regulate the activity of skeletal muscle stem cells. The aims are to identify the metabolic factors that regulate muscle stem cell identity and to examine how changes in the local metabolic environment can influence how stem cells respond to biological perturbations. This project will reveal novel mechanisms by which skeletal muscle stem cells can be regulated. This information is crucial for our fundamental understanding of stem cell biology and its future applications.

Funding

Australian Research Council (ARC)

Research Group

Lynch laboratory: Basic and clinical myology



Faculty Research Themes

Neuroscience

School Research Themes

Biomedical Neuroscience, Stem Cells



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology

Unit / Centre

Lynch laboratory: Basic and clinical myology