Therapeutic Potential of Heat Shock Protein 72 Induction in Muscular Dystrophy

Project Details

Muscle wasting and weakness are major symptoms of many neuromuscular disorders, including Duchenne muscular dystrophy (DMD).  Although considerable efforts are being directed to the development of gene and cell therapies for DMD, these techniques are far from perfected. In the interim, it is essential that alternative therapies be developed, and research directed to preserving muscle tissue, enhancing muscle regeneration, and promoting muscle growth.  Therapeutic strategies are needed to ameliorate the dystrophic pathology and enhance patient quality of life. A successful pharmacological approach may enable patients to survive and thus take advantage of gene therapies when they eventually become available. Through the generous support of the MDA (USA), this project examines the therapeutic potential of Hsp72 upgregulation to ameliorate the cardiomyopathy and skeletal muscle wasting in two animal models of DMD, the mdx mouse and the DKO mouse.

Funding

Muscular Dystrophy Association U.S.A. (MDA)

Research Group

Lynch Laboratory: Basic and Clinical Myology



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Physiology