Therapeutic potential of Heat Shock Protein 72 induction in muscular dystrophy
Muscle wasting and weakness are major symptoms of many neuromuscular disorders, including Duchenne muscular dystrophy (DMD). Although considerable efforts are being directed to the development of gene and cell therapies for DMD, these techniques are far from perfected. In the interim, it is essential that alternative therapies be developed, and research directed to preserving muscle tissue, enhancing muscle regeneration, and promoting muscle growth. Therapeutic strategies are needed to ameliorate the dystrophic pathology and enhance patient quality of life. A successful pharmacological approach may enable patients to survive and thus take advantage of gene therapies when they eventually become available. Through the generous support of the MDA (USA), this project examines the therapeutic potential of Hsp72 upgregulation to ameliorate the cardiomyopathy and skeletal muscle wasting in two animal models of DMD, the mdx mouse and the DKO mouse.
Muscular Dystrophy Association U.S.A. (MDA)