Role of SOCS3 in defective muscle repair during ageing
In mammals, ageing is associated with progressive muscle wasting and weakness (sarcopenia). Our preliminary findings indicate that SOCS3 protein expression is reduced in old skeletal muscle and we suggest that this leads to defects in the signalling pathways controlling muscle growth and repair resulting in the decline in muscle structure and function during ageing. Using cutting-edge techniques in cell biology and molecular physiology our goals are to understand how SOCS3 affects muscle regeneration and identify ways to enhance the capacity of older muscles to regenerate successfully after injury. Ultimately, the findings will help enable old muscles to perform as well as young muscles. The aim of this project is to identify the SOCS3 dependent mechanisms that regulate muscle growth and repair and which of these are responsible for the deleterious changes in skeletal muscle during ageing. Better understanding of the signaling pathways responsible for maintaining muscle structure and function will enable us to identify novel targets and strategies to ameliorate age-related effects. Ultimately, this work could lead eventually to interventions that improve functional independence and allow Australians to age well and to live more productive lives.
Australian Research Council (ARC)
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