Heat Shock Protein Therapy For Muscle Wasting
Muscle wasting is an urgent and unmet health risk associated with ageing/frailty; cancers; renal, respirator and cardiac insufficiency; disuse; nerve injury; unloading; sepsis; burns; AIDS; and muscular diseases. These conditions are linked by the inflammation, atrophy and weakness common to their pathophysiology.
Heat shock proteins help stressed proteins fold back to their original conformation and restore function. In a discovery published in Nature we identified induction of heat shock protein 72 (Hsp72) as a novel approach for muscular dystrophy and other conditions where there is inflammation and muscle weakness. This proposal will investigate whether Hsp72 induction is similarly effective in tackling the muscle wasting and weakness in conditions like ageing and frailty and in muscle injury.
Using established animal models of muscle wasting, injury and repair, this project aims to determine the therapeutic potential of Hsp72 induction to attenuate muscle wasting and weakness with disuse atrophy and age-related muscle wasting and weakness (sarcopenia). We also aim to determine whether Hsp72 induction has therapeutic potential for enhancing muscle regeneration and function after injury. The findings are critical for developing treatments for millions of patients worldwide who have suffered injuries in workplace and motor vehicle accidents, on the sports field and battleground.
National Health & Medical Research Council
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School Research Themes
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