Crack laboratory: Neuropharmcology

Research Overview

Projects for Honours and PhD

  • How a pro-oxidant state and increased reactive oxygen species affect cellular signal transduction systems.
  • The role of oxidative stress in the regulation of Interleukin-6 and implications for neurological disease.
  • The involvement of the Toll-Like Receptor family in the progression of neural inflammation and neural injury.
  • Genomic profile of the brain after traumatic brain injury.

Staff

Dr Juliet Taylor, Postdoctoral Research Fellow
Dr Moses Zhang, Research Assistant
Ms Ila Karve, PhD Student
Mr Myles Minter, PhD Student
Mr Bevan Main, PhD Student

photo of staff from neuropharmacology lab

Collaborators

Dr Ashley Mansell, Monash Institute of Medical Research
Dr Michael Hickey, Monash Institute of Medical Research
Professor Paul Hertzog, Monash Institute of Medical Research
Professor Norman Saunders, University of Melbourne
Dr Chris Sobey, Department of Pharmacology, Monash University
Apollo Biosciences
Victorian Neurotrauma Research Consortium
Associate Professor Tony Tiganis, Monash University
Professor Owen Woodman, RMIT University

Funding

Victorian Trauma Foundation
Rebecca Cooper Foundation
NHMRC Project Grant #509018

Research Publications

  1. Crack PJ, Taylor JM, Ali U, Mansell A, Hertzog PJ.
    NF-kB mediated neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury.
    Stroke 2006; in press.
  2. Mansell A, Smith R, Doyle S, Gray P, Fenner J, Crack PJ, Nicolson S, Hilton D, O'Neill L, Hertzog PJ.
    Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll like receptor signaling by targeting Mal for degradation.
    Nature Immunology 2006; 7(2): 148-55. News and Views, p123-24.
  3. Crack PJ, Taylor JM.
    Reactive oxygen species and the exacerbation of stroke.
    Free Radical Biology and Medicine 2005; 38(11): 1433-44.
  4. Taylor JM, Iannello RC, Hertzog PJ, Crack PJ.
    Diminished Akt phosphorylation in neurons lacking Gpx1 leads to increased susceptibility to oxidative stress-induced cell death.
    Journal of Neurochemistry 2005; 92(2): 283-93.
  5. Taylor JM, *Crack PJ, Gould JA, Ali U, Hertzog PJ, Iannello RC.
    Akt phosphorylation and NFkB activation are counter-regulated under conditions of oxidative stress.
    Experimental Cell Research 2004; 300(2): 463-475.
  6. Crack PJ, Taylor JM, de Haan JB, Kola I, Hertzog P, Iannello RC.
    Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury.
    Journal of Cerebral Blood Flow and Metabolism 2003; 23(1): 19-22.
  7. Crack PJ, Taylor JM, Flentjar NJ, deHaan J, Hertzog P, Iannello RC, Kola I.
    Increased Infarct size and Exacerbated Apoptosis in the Glutathione Peroxidase-1 Knockout Mouse Brain in Response to Ischemia/Reperfusion Injury.
    Journal of Neurochemistry 2001; 78(6): 1989-1999

Research Projects



Faculty Research Themes

Neuroscience

School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact Associate Professor Peter Crack

Department / Centre

Pharmacology and Therapeutics

Unit / Centre

Crack laboratory: Neuropharmcology