Regulation of Mast Cell Activation

Project Details

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The laboratory has long-standing interests in controlling IgE-dependent mast cell activation, both through regulating the IgE/FcεRI interaction and modulating intracellular signal transduction. Current projects are examining small molecule inhibitors of IgE binding and examining the role of newly identified guanine nucleotide exchange factors (GEFs) in controlling mast cell degranulation and cytokine release.

Model of the interaction between IgE and FcεRIα.

Figure 1 : Model of the interaction between IgE and FcεRIα.

Research Group

Anti-allergic Therapeutics



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Pharmacology and Therapeutics