Novel Mast Cell-Derived Mediators

Project Details

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We have identified several novel mast cell derived factors that we have shown activate airway 'structural' cells such as smooth muscle, epithelium and fibroblasts. Work is ongoing to identify the mechanisms responsible for this effect and its importance in human inflammatory disease. We are also developing strategies to block the actions of these novel mast cell factors

Figure 1: Mast cells and basophils release potent mediators upon activation of IgE/FcεRI.

Figure 1: Mast cells and basophils release potent mediators upon activation of IgE/FcεRI.

Research Group

Anti-allergic Therapeutics



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Pharmacology and Therapeutics