Characterisation of cerebrovascular reactivity to vasoactive agents, in particular adrenoceptors and endothelin receptors
Abnormal vasomotor reactivity is implied in the aetiology of various disorders of the cerebral circulation including aneurysmal haemorrhage. This study explored the mechanisms involved in cerebrovascular responses to vasoactive substances that have been causally linked to the dysregulation of cerebral blood flow with a major emphasis on effects of endothelin and noradrenaline. The majority of the study was conducted in rat isolated cerebral arteries using myography techniques, together with some in vivo rat and clinical studies.
Figure 1: Mr Yohannes Mamo, PhD candidate, studies small cerebrovascular resistance arteries using wire myography.