Characterisation of cerebrovascular reactivity to vasoactive agents, in particular adrenoceptors and endothelin receptors

Project Details

Abnormal vasomotor reactivity is implied in the aetiology of various disorders of the cerebral circulation including aneurysmal haemorrhage. This study explored the mechanisms involved in cerebrovascular responses to vasoactive substances that have been causally linked to the dysregulation of cerebral blood flow with a major emphasis on effects of endothelin and noradrenaline. The majority of the study was conducted in rat isolated cerebral arteries using myography techniques, together with some in vivo rat and clinical studies.

Mr Yohannes Mamo, PhD candidate, studies small cerebrovascular resistance arteries using wire myography.

Figure 1: Mr Yohannes Mamo, PhD candidate, studies small cerebrovascular resistance arteries using wire myography.

Research Group

Wright laboratory: Cardiovascular



Faculty Research Themes

Neuroscience

School Research Themes

Biomedical Neuroscience, Therapeutics & Translation



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Pharmacology and Therapeutics

Unit / Centre

Wright laboratory: Cardiovascular