Effects of hypertension on renal and hindquarter vascular reactivity in vivo and in vitro

Project Details

Hypertension is one of the most common conditions, with the number of sufferers projected to reach 1.56 billion individuals by 2025. Particular vascular regions have been implicated in blood pressure control and the important blood vessels involved in this control are the small arterioles, often called resistance (to blood flow) vessels. However, vascular responsiveness to physiological factors and exogenous substances (e.g. antihypertensive drugs) are not always uniform across these resistance vessels. Moreover, as hypertension progresses, vascular beds undergo aberrant structural changes to varying extents, further altering the local properties and functional responses in each region; these may explain the ineffectiveness of antihypertensive therapies in some patients. Characterisation of the local properties of various resistance vessels in normotensive and hypertensive settings will enhance our understanding of blood pressure control and assist the development of more effective therapies. The renal vasculature is of particular interest as the kidneys regulate blood flow and blood volume. The hindquarter vasculature is representative of a skeletal muscle vascular bed and is controlled by factors that are somewhat different to the kidney due to the differing requirements of muscle. In chronic hypertension, there is often concomitant peripheral vascular disease in lower limbs, which alters vascular responsiveness. This work will examine hindquarter and renal haemodynamics under a range of conditions in vivo, and isolated renal arterioles in vitro. The contribution of T-type voltage-operated calcium channels to rat renal vascular tone will also be functionally characterised.

Researchers

Professor James A. Angus, AO, BSc Hons, PhD, FAA, FAHMS (Hon),

Mr Mark Ross-Smith, BSc Hons, Senior Research Assistant

Ms Linda Cornthwaite-Duncan, Technical Officer

Collaborators

Dr Makhala Khammy, Ion Channel Group, Vascular Physiology, Department of Biomedical Sciences, University of Copenhagen & Aarhus University, Denmark

Funding

Miscellaneous Grants

Research Publications

  • Angus JA, Korner PI, Wright CE. Pharmacology and the elucidation of function. Trends Pharmacol Sci 2011; 32: 235-241.
  • Khammy MM, Angus JA, Wright CE. Vascular reactivity of rabbit isolated renal and femoral resistance arteries in renal wrap hypertension. Eur J Pharmacol 2016; 773: 32-41.
  • Korner PI, Wright CE, Angus JA. A new approach to assessing the structural total peripheral resistance amplifier in renal (Page) hypertension in conscious rabbits. J Hypertens 2010; 28: 1862-1874.

Research Group

Wright laboratory: Cardiovascular Therapeutics Unit


School Research Themes

Cardio-Respiratory



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Pharmacology and Therapeutics

Unit / Centre

Wright laboratory: Cardiovascular Therapeutics Unit