Isolation and Characterization of Major Venom Proteins From Scyphozoan Jellyfish
Isolation and characterization of major venom proteins from Scyphozoan jellyfish using proteomic, transcriptomic and pharmacological approaches
Jellyfish venoms are rich sources of bioactive compounds, however few toxins have been completely isolated and characterized. Basic research investigating the proteomes of jellyfish venoms may lead to the discovery of promising compounds for the development of therapeutic agents or probes to study physiological pathways. The Scyphozoans, or 'true' jellyfish, have been somewhat neglected for toxin studies, compared to the more dangerous box jellyfish. Proteomic, transcriptomic and pharmacological studies are essential to identify and isolate toxic proteins/peptides as well as to elucidate their structures, mechanisms of action and molecular targets. In collaboration with the Cardiovascular Therapeutics Unit, the Tennessee Aquarium, the Australian Institute of Marine Sciences in Townsville and the Queensland Institute of Medical Research in Brisbane, we are working with venoms from the Atlantic sea nettle, Chrysaora quinquecirrha, and the Pacific sea nettle, Chrysaora fuscescens, in order to explore the proteomics and transcriptomics of each venom and characterise the pharmacological activities of crude venoms and isolated toxins using in vitro and in vivo bioassays.
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