The Molecular Basis of the Propagation of Molecular Strain Types of Prions

Project Details

The enteric nervous system is the division of the autonomic nervous system that provides intrinsic control of the gastrointestinal system. We have shown that following intracerebral inoculation, prions can be found in the gastrointestinal tract where they cause pathological changes in neurons and glia cells (Lawson et al Gut 2010). Current research is focused on understanding the cause of neuronal and glia cell changes and the consequence of these changes on gastrointestinal function and disease transmission.

Techniques

Pathology (in vivo models, immunohistochemistry, western immunoblot, neurophysiology).

Research Group

Lawson Laboratory: Neurodegenerative Disease Caused by Prions



Faculty Research Themes

Neuroscience, Infection and Immunology

School Research Themes

Neuroscience, Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Pathology