The role of glycosaminoglycan in the propagation of prions
The most common form of prion disease arises through the spontaneous misfolding of the prion protein. These sporadic forms of the disease are a particular challenge to healthcare as they cannot be diagnosed preclinically and are a potential source of disease transmission.
It has been shown that spontaneous misfolding can be induced in the prion protein in the presence of cofactors. However, it has not yet been shown how these cofactors may contribute to disease in vivo. The Lawson lab is investigating ways to manipulate the cellular environment to cause spontaneous misfolding of the prion protein.
- cell biology (in vitro cell culture, immunfluoresence)
- molecular biology (protein expression, RNAi, qRT-PCR)
- biochemistry (western immunoblot analysis)
- pathology (in vivo models).
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For further information about this research, please contact the research group leader.