Regulators of plasticity and treatment response in colorectal cancer

Project Details

National

Professor Alexander Heriot, Professor Robert Ramsey, Peter Mc Callum Cancer Centre, Melbourne
Dr Erica Sloan - Monash Institute of Pharmaceutical Sciences, Monash University Dr Melissa Davis, Prof Edmund Crampin, Systems Biology Laboratory, The University of Melbourne
Dr Davide Ferrari, School of Mathematics and Statistics, The University of Melbourne Dr Kara Perrow, School of Biological Sciences, University of Wollongong, NSW.

International

Dr. Julie Pannequin/Dr Jean Marc Pascussi, Institute of Functional Genomics, Montpellier, France

Researchers

Dr. Christina Molck (PhD), Post-doctoral Research Fellow (Danish Cancer Foundation)
Ms. Laura Marie Failla, Research Assistant
Dr. Adityas Purnianto (MD), Masters Student
Dr. Corina Behrenbruch (MBBS), PhD Student (from Jan 2016)
Ms Carolyn Shembrey, Honours Student (from Feb 2016)

Collaborators

National

Professor Alexander Heriot, Professor Robert Ramsey, Peter Mc Callum Cancer Centre, Melbourne

Dr. Erica Sloan - Monash Institute of Pharmaceutical Sciences, Monash University

Dr. Melissa Davis, Prof Edmund Crampin, Systems Biology Laboratory, The University of Melbourne

Dr. Davide Ferrari, School of Mathematics and Statistics, The University of Melbourne

Dr Kara Perrow, School of Biological Sciences, University of Wollongong, NSW.

International

Dr Julie Pannequin/Dr Jean Marc Pascussi, Institute of Functional Genomics, Montpellier, France

Research Publications

  • Aeson Chang, Corina Kim-Fuchs, Caroline P. Le, Frederic Hollande, Erica K. Sloan. Neural Regulation of Pancreatic Cancer: A Novel Target for Intervention. Cancers 2015 Jul 17;7(3):1292-312. doi: 10.3390/cancers7030838.
  • Breuker C, Planque C, Nault JC, Couchy G, Zucman-Rossi J, Evrard A, Kantar J, Chevet E, Bioulac-Sage P, Ramos J, Assenat E, Joubert D, Pannequin J, Hollande F, Pascussi JM. Characterization of a novel PXR isoform with potential dominant-negative properties. J Hepatol 2014 Sep;61(3): 609-16.
  • Corina Kim-Fuchs, Caroline P. Le, Matthew A. Pimentel, David Shackleford, Davide Ferrari, Eliane Angst, Frédéric Hollande, Erica K. Sloan. Chronic stress accelerates pancreatic cancer growth and invasion:  A critical role for beta-adrenergic signaling in the pancreatic microenvironment. Brain, Behavior, and Immunity 2014 Aug;40:40-7.
  • Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, Crespy P, Journot L, Hollande F* and Joubert D*. Essential requirement for beta-arrestin2 in mouse intestinal tumors with elevated Wnt signaling. (*Joint supervising authors). Proc Natl Acad Sci USA. 2012 Feb 21;109(8): 3047-52.
  • Raynal C, Pascussi JM, Leguelinel G, Breuker C, Kantar J, Lallemant B, Poujol S, Joubert D, Hollande F, Lumbroso S, Brouillet JP and Evrard A.  Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. Molecular Cancer 2010;Mar 2;9:46.
  • Hollande F., Pannequin J., and Joubert D. The long road to colorectal cancer therapy: searching for the right signals. Drug Resistance Updates 2010;Feb-Apr;13(1-2):44-56.
  • Pannequin J, Bonnans C, Delaunay N, Ryan J, Bourgaux JF, Joubert D, and Hollande, F.  The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells. Cancer Res 2009;69(15): 6065-73.

Research Group

Hollande laboratory: Molecular mechanisms of tumour progression



Faculty Research Themes

Cancer

School Research Themes

Cancer in Biomedicine, Cell Signalling, Molecular Mechanisms of Disease, Therapeutics & Translation, Stem Cells



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Pathology

Unit / Centre

Hollande laboratory: Molecular mechanisms of tumour progression