Parkinson's disease

Project Details

PD is a movement disorder caused by the loss of neurons from the substantia nigra. The key pathological hallmark of PD is the intracellular inclusions called Lewy bodies which are composed mainly of the α-synuclein protein.

Structural properties of α-synuclein

The α-synuclein protein is a cytoplasmic protein that undergoes a structural transition from an unfolded state into an α-helical containing conformation. We have been studying the factors that modulate this structural change and found that dopamine and lipids can alter the biophysical properties of α-synuclein. Our goal is to relate these in vitro studies to the pathological pathways that occur in PD.

Research Group

Cappai laboratory: Alzheimer's disease, prion disease, Parkinson's disease and Traumatic Brain Injury



Faculty Research Themes

Neuroscience

School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Pathology

Unit / Centre

Cappai laboratory: Alzheimer's disease, prion disease, Parkinson's disease and Traumatic Brain Injury