Mackay (L) laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity

  • Senior Lecturer & NHMRC Career Development Fellow, HHMI-Gates International Research Scholar

    Dr Laura Mackay
    T: +61 3 8344 8016
    E: lkmackay@unimelb.edu.au
    Location: Level 8, Rm 8009, Peter Doherty Institute, Parkville
    W: Personal web page

Research Overview

Laura's group studies cellular immune responses, with a focus on the genes and signals that control resident memory T cell differentiation, with a view to harness these cells to develop new treatments against infection, cancer, and autoimmune disease.

Staff

David Freestone, Research Assistant
Brooke Davies, Research Assistant
Susan Christo, Research Officer
Julia Prier, Research Officer
Natasha Zamudio, Research Officer

Erica Wynne-Jones, PhD student
Simone Park, PhD student
Clara Castellucci, PhD student

Research Opportunities

This research project is available to PhD, Masters, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

  1. Davies B. Prier JE, Jones CM, Gebhardt T, Carbone FR, Mackay LK*. Cutting Edge: Tissue-Resident Memory T Cells Generated by Multiple Immunizations or Localized Deposition Provide Enhanced Immunity. J Immunol 2017; 198: 2233-37. *Corresponding author.
  2. Gregory JL, Walter A, Alexandre YO, Hor JL, Liu R, Ma JZ, Devi S, Tokuda N, Owada Y, Mackay LK, Smyth GK, Heath WR,  Mueller SN. Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge. Cell Reports 2017; 18(2): 406-418. IF: 7.87
  3. Mackay LK*, Kallies A.  Transcriptional regulation of Tissue-Resident Lymphocytes. Trends Immunol 2017;  38(2): 94-103. IF: 11.4 *Corresponding author.
  4. Koay HF, Gherardin NA, Enders A, Loh L, Mackay LK, Almeida CF, Russ BE, Nold-Petry CA, Nold MF, Bedoui S., Chen Z., Corbett A.J., Eckle S.B., Meehan B., d'Udekem Y., Konstantinov I.E., Lappas M., Liu L., Goodnow CC, Fairlie DP, Rossjohn J, Chong MM, Kedzierska K, Berzins SP, Belz GT, McCluskey J, Uldrich AP, Godfrey DI, Pellicci DG.  Thymic precursors to the Mucosal-Associated Invariant T cell lineage. Nat Immunol 2016; 17(11): 1300-11. IF: 26.1
  5. Park SL, Mackay LK*, Gebhardt T*.  Distinct recirculation potential of CD69+CD103- and CD103 thymic memory CD8 T cells. Immunol Cell Biol 2016; 94: 975-980. *Corresponding authors.
  6. Mackay LK*, Minnich M, Kragten NAM, Liao Y, Nota B, Seillet C, Zaid A, Man K, Preston S, Freestone D, Braun A, Wynne-Jones E, Behr FM, Stark R, Pellicci DG, Godfrey DI, Belz GT, Pellegrini M, Gebhardt T, Busslinger M, Shi W, Carbone FR, van Lier RAW, Kallies A, van Gisbergen KPJM. Hobit and Blimp1 instruct a universal transcriptional program of tissue-residency in lymphocytes. Science 2016; 352(6284): 459-63  IF:33.6 *Corresponding author
  7. Mueller SN*, Mackay LK*.  Tissue-resident memory T cells: local specialists in immune defence. Nat Rev Immunol 2016; 16: 79-89. *Corresponding authors.
  8. Mackay LK, Wynne-Jones E, Freestone D, Pellicci DG, Braun A, Kallies A, Belz GT, Carbone FR.  T-box transcription factors combine with the cytokines TGF-β and IL-15 to control tissue-resident memory T cell fate. Immunity 2015; 43(6):1101-11. 
  9. Mackay LK.  Mannose-6-phosphate receptor delivers the death sentence. J Leukoc Biol 2015; 98: 299-300.
  10. Mackay LK*, Carbone FR. Skin-resident T cells keep parasites on a Leash. J Exp Med 2015; 212(9): 1340-1. *Corresponding author.
  11. Mackay LK*, Braun A, Macleod BL, Collins N, Tebartz C, Bedoui S, Carbone FR, Gebhardt T.  Cutting Edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J Immunol 2015; 194(5): 2059-63.  *Corresponding author
  12. Mackay LK, Carbone FR. CD4 helpers put tissue-resident memory cells in their place. Immunity 2014; 41(4): 514-515.
  13. Zaid A, Mackay LK, Rahimpour A, Braun A, Veldhoen M, Carbone FR, Manton JH, Heath WR, Mueller SN.  Persistence of skin resident memory T cells within an epidermal niche. Proc Nat Acad Sci USA 2014; 111(14): 5307-5312.
  14. Mackay LK, Rahimpour A, Ma JZ, Collins N, Stock AT, Hafon M, Vega-Ramos J, Lauzurica P, Stefanovic T, Tscharke D, Heath WR, Inuoye M, Gebhardt T, Carbone FR. The development pathway for CD103+CD8+ tissue-resident memory T cells (TRM) of skin. Nature Immunol 2013; 14(12): 1294-301.
  15. Mackay LK, Gebhardt T. Tissue-resident memory T cells: Local guards of the thymus. Eur J Immunol 2013; 43(9): 2259-62.
  16. Gebhardt T, Mackay LK. Skin-resident memory T cells keep herpes simplex virus at bay. Immunol Cell Biol 2013; 91: 441-442.
  17. Carbone FR, Mackay LK, Heath WR, Gebhardt T.  Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues. Curr Opin Immunol 2013; 23: 329-33.
  18. Gebhardt T, Mackay LK. Local immunity by tissue-resident CD8+ memory T cells. Front Immunol 2012: 3: 340. doi: 10.3389/fimmu.2012.00340.
  19. Mackay LK, Stock AT, Ma JZ, Jones CM, Kent SJ, Mueller SN, Heath WR, Carbone FR, Gebhardt T.  Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc Nat Acad Sci USA 2012; 109(18): 7037-7042.
  20. Mackay LK, Wakim L, van Vliet CJ, Jones CM, Bannard O, Fearon DT, Heath WR, Carbone FR. Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol 2012; 188: 2173-2178.
  21. Gebhardt T, Whitney PG, Zaid A, Mackay LK, Brooks AG, Heath WR, Carbone FR, Mueller SN. Different patterns of peripheral migration by memory CD4(+) and CD8(+) T cells.  Nature 2011: 477: 216-219.
  22. Leung CK, Haigh TA, Mackay LK, Rickinson AB, Taylor GS.  MHC II-restricted presentation of an endogenously expressed nuclear antigen, EBNA1: nuclear location restricts access to macro-autophagy and the range of epitope display. Proc Nat Acad Sci USA 2010; 107(5): 2165-2170.
  23. Mackay LK, Long HM, Brooks JM, Taylor GS, Leung CK, Chen A, Wang F, Rickinson AB.  Newly-synthesised polypeptides versus mature protein as endogenous antigen sources for MHC I- and MHC II-restricted T cell recognition. PLoS Pathogens 2009; 5(12):e 10000699.