Mackay (L) laboratory: Tissue-resident memory T cells; lymphocyte differentiation; peripheral immunity

Research Overview

Currently not available

Staff

Brooke Davies, Research Assistant
David Freestone, Research Assistant
Erica Wynne-Jones, PhD student
Simone Park, PhD student

Research Publications

  1. Mackay LK. (2015) Mannose-6-phosphate receptor delivers the death sentence. J Leukoc Biol In Press.
  2. Mackay LK, Carbone FR. (2015) Skin-resident T cells keep parasites on a Leash. J Exp Med In Press.
  3. Mackay LK, Braun A, Macleod BL, Collins N, Tebartz C, Bedoui S, Carbone FR, Gebhardt T. (2015) Cutting Edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J Immunol 194(5): 2059-63.
  4. Mackay LK, Carbone FR. (2014) CD4 helpers put tissue-resident memory cells in their place. Immunity 41(4): 514-515.
  5. Zaid A, Mackay LK, Rahimpour A, Braun A, Veldhoen M, Carbone FR, Manton JH, Heath WR, Mueller SN. (2014) Persistence of skin resident memory T cells within an epidermal niche. Proc Nat Acad Sci USA 111(14): 5307-5312.
  6. Mackay LK, Rahimpour A, Ma JZ, Collins N, Stock AT, Hafon M, Vega-Ramos J, Lauzurica P, Stefanovic T, Tscharke D, Heath WR, Inuoye M, Gebhardt T, Carbone FR. (2013) The development pathway for CD103+CD8+ tissue-resident memory T cells (TRM) of skin. Nature Immunol 14(12): 1294-301.
  7. Mackay LK, Gebhardt T. (2013) Tissue-resident memory T cells: Local guards of the thymus. Eur J Immunol 43(9): 2259-62.
  8. Gebhardt T, Mackay LK. (2013) Skin-resident memory T cells keep herpes simplex virus at bay. Immunol Cell Biol 91: 441-442.
  9. Carbone FR, Mackay LK, Heath WR, Gebhardt T. (2013) Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues. Curr Opin Immunol 23: 329-33.
  10. Gebhardt T, Mackay LK. (2012) Local immunity by tissue-resident CD8+ memory T cells. Front Immunol 3: 340. doi: 10.3389/fimmu.2012.00340.
  11. Mackay LK, Stock AT, Ma JZ, Jones CM, Kent SJ, Mueller SN, Heath WR, Carbone FR, Gebhardt T. (2012) Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc Nat Acad Sci USA 109(18): 7037-7042.
  12. Mackay LK, Wakim L, van Vliet CJ, Jones CM, Bannard O, Fearon DT, Heath WR, Carbone FR. (2012) Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol 188: 2173-2178.
  13. Gebhardt T, Whitney PG, Zaid A, Mackay LK, Brooks AG, Heath WR, Carbone FR, Mueller SN. (2011) Different patterns of peripheral migration by memory CD4(+) and CD8(+) T cells.   Nature 477: 216-219.
  14. Leung CK, Haigh TA, Mackay LK, Rickinson AB, Taylor GS. (2010) MHC II-restricted presentation of an endogenously expressed nuclear antigen, EBNA1: nuclear location restricts access to macro-autophagy and the range of epitope display. Proc Nat Acad Sci USA 107(5):2165-2170.
  15. Mackay LK, Long HM, Brooks JM, Taylor GS, Leung CK, Chen A, Wang F, Rickinson AB. (2009) Newly-synthesised polypeptides versus mature protein as endogenous antigen sources for MHC I- and MHC II-restricted T cell recognition. PLoS Pathogens 5(12):e10000699.

Research Projects



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact Dr Laura Mackay

Department / Centre

Microbiology and Immunology