Deciphering the relative contributions of different dendritic cells to killer T cell responses

Project Details

Continuing our endeavor to resolve the role of dendritic cells (DC) in virus infections, this project investigates the relative contributions of different DC subtypes to killer T cell priming and examines the molecular pathways involved (direct vs. cross-presentation). Utilizing in vivo models that remove the capacity of cells to directly present viral antigen, we found that robust virus-specific killer T cell responses depend on cross-presentation. We are currently delineating the underlying mechanisms.

scheme

Research Group

Bedoui laboratory: Innate and adaptive interactions in immunity to infection



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

Unit / Centre

Bedoui laboratory: Innate and adaptive interactions in immunity to infection