Tissue-resident memory T cells in the skin

Project Details

Protection from viral infections that target peripheral tissues such as the skin requires coordinated recruitment of pathogen-specific T lymphocytes into the tissue where they function to defeat the virus. Following the resolution of HSV-1 infection or inflammation in the skin, tissue-resident memory (Trm) CD8+ T cells reside for long periods in the epidermis where they can provide enhanced protection from reinfection. These tissue-resident T cells display a unique dendritic morphology and a slow pattern of tissue surveillance (Movie 1). We are examining how these Trm cells are formed, persist and respond following secondary infection.

Movie 1: Tissue-resident CD8 T cells (green) migrating in the epidermis of the skin.
Collagen (SHG), blue.

Research Publications

  1. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.
    Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN, Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF, Freeman AF, Cornall RJ, Germain RN, Mueller SN, Su HC.
    J Exp Med 2014 Dec 15;211(13):2549-66. doi: 10.1084/jem.20141307. Epub 2014 Nov 24. PMID: 25422492
  2. Persistence of skin-resident memory T cells within an epidermal niche.
    Zaid A, Mackay LK, Rahimpour A, Braun A, Veldhoen M, Carbone FR, Manton JH, Heath WR, Mueller SN.
    Proc Natl Acad Sci U S A 2014 Apr 8;111(14):5307-12. doi: 10.1073/pnas.1322292111. Epub 2014 Mar 24. PMID: 24706879
  3. Memory T cell subsets, migration patterns, and tissue residence.
    Mueller SN, Gebhardt T, Carbone FR, Heath WR.
    Annu Rev Immunol 2013;31:137-61. doi: 10.1146/annurev-immunol-032712-095954. Epub 2012 Dec 3. PMID: 23215646
  4. Different patterns of peripheral migration by memory CD4+ and CD8+ T cells.
    Gebhardt T, Whitney PG, Zaid A, Mackay LK, Brooks AG, Heath WR, Carbone FR, Mueller SN.
    Nature 2011 Aug 14;477(7363):216-9. doi: 10.1038/nature10339. PMID: 21841802