Tissue-resident Memory T Cells in The Skin
Protection from viral infections that target peripheral tissues such as the skin requires coordinated recruitment of pathogen-specific T lymphocytes into the tissue where they function to defeat the virus. Following the resolution of HSV-1 infection or inflammation in the skin, tissue-resident memory (Trm) CD8+ T cells reside for long periods in the epidermis where they can provide enhanced protection from reinfection. These tissue-resident T cells display a unique dendritic morphology and a slow pattern of tissue surveillance (Movie 1). We are examining how these Trm cells are formed, persist and respond following secondary infection.
Movie 1: Tissue-resident CD8 T cells (green) migrating in the epidermis of the skin.
Collagen (SHG), blue.
- DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.
Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN, Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF, Freeman AF, Cornall RJ, Germain RN, Mueller SN, Su HC.
J Exp Med 2014 Dec 15;211(13):2549-66. doi: 10.1084/jem.20141307. Epub 2014 Nov 24. PMID: 25422492
- Persistence of skin-resident memory T cells within an epidermal niche.
Zaid A, Mackay LK, Rahimpour A, Braun A, Veldhoen M, Carbone FR, Manton JH, Heath WR, Mueller SN.
Proc Natl Acad Sci U S A 2014 Apr 8;111(14):5307-12. doi: 10.1073/pnas.1322292111. Epub 2014 Mar 24. PMID: 24706879
- Memory T cell subsets, migration patterns, and tissue residence.
Mueller SN, Gebhardt T, Carbone FR, Heath WR.
Annu Rev Immunol 2013;31:137-61. doi: 10.1146/annurev-immunol-032712-095954. Epub 2012 Dec 3. PMID: 23215646
- Different patterns of peripheral migration by memory CD4+ and CD8+ T cells.
Gebhardt T, Whitney PG, Zaid A, Mackay LK, Brooks AG, Heath WR, Carbone FR, Mueller SN.
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