Nervous regulation of T cell migration and anti-viral Immunity

Project Details

The lymphoid organs are innervated by fibres of the sympathetic nervous system (SNS), which release SNS neurotransmitters during times of chronic stress. SNS neurotransmitters bind to beta-adrenoceptors (╬▓ARs) on multiple cell types to induce genomic and functional changes. However, little is known about the impact of SNS neurotransmitters on immune cell function or their role in anti-viral immunity. Studies have shown that viral immunity is compromised during times of chronic stress raising the possibility that SNS signalling impairs anti-viral immunity by impacting T cell activation, migration or effector functions. This project is examining the effect of adrenergic receptor signalling in T cells on their migration within tissues such as the lymph nodes and subsequent immune responses to viral infections.

Collaborators

Dr Erica Sloan, Monash University.