Understanding ‘Universal’ Influenza-Specific CD8+ T Cell Responses
Although CD8+ T-cells confer universal immunity to distinct influenza viruses and may limit influenza-induced mortality, the overall efficacy of human influenza A virus-specific CD8+ T cells directed at any conserved and/or variable epitopes remains unclear. Here, we aim to:
- understand influenza-specific CD8+ T-cell immunity across different HLAs;
- determine the efficacy of immunodominant CD8+ T-cell responses in humans;
- evaluate the conservation of immunogenic epitopes in birds, pigs and humans through analysis of viral evolutionary history (with A/Prof Vijaykrishna; Duke-NUS, Singapore);
- understand immunity to clinically important but understudied influenza B viruses.
Faculty Research Themes
School Research Themes
For further information about this research, please contact the research group leader.