Mechanisms underlying early generation of human T cell memory

Project Details

Though immunological memory is of pivotal importance for vaccine development and immunotherapy, the molecular and differentiation pathways central to the generation of (particularly) human CD8+ T-cell memory are poorly understood. Here, we aim to:

  1. establish the key factors driving the early establishment of influenza-specific T cell memory;
  2. To define molecular processes involved in CD27-mediated co-stimulation of human T cells. As memory is crucial for protection against recurrent infections, this work will provide novel insights into the generation and efficacy of human T cell memory populations and inform effective CD27-mediated stimulation for immunotherapy.

Research Group

Kedzierska laboratory: Immunity to pandemic and newly emerged influenza viruses



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology