Jackson laboratory: Synthetic vaccine design
The research interests of the laboratory centre around the discovery and development of novel and innovative vaccine candidates. Using the techniques of chemical synthesis and molecular biology and/or a combination of both, we have developed vaccines for a variety of disease indications from infectious diseases to hormone blockade and substances of abuse including cocaine and methamphetamine.
A dominant strategy of these research efforts is to design the vaccine rationally; in other words to only include those components that are necessary for the desired and appropriate immune outcome. This means that we can remove unnecessary and sometimes dangerous components to provide safer vaccines that elicit antibody and/or cell-mediated immune responses. We also build into our vaccines an ability to be highly immunogenic, a feature that obviates the addition of extraneous adjuvants.
The laboratory has approximately ten members consisting of post doctoral fellows, research assistants and PhD students with undergraduate students providing a continuous flow of new talent each year. The laboratory operates through individual research efforts and through partnerships that are formed between one or more laboratory members and which are driven by unmet medical needs and the skills that are possessed by the various team members. Some of the projects and programs currently running in our laboratory are described below. Opportunities exist for motivated, intelligent and committed scientists to join the laboratory.
- Biolpolymer-based vaccine delivery systems
- A universal vaccine against influenza A
- Lipopeptide-based adjuvanting systems
- Innovative approaches to prepare synthetic, partially synthetic and natural product-based vaccines
- Development of a self-adjuvanting vaccine for enterotoxigenic Escherichia coli (ETEC)
- The innate immune system in the respiratory tract
Faculty Research Themes
School Research Themes
For further information about this research, please contact Professor David Jackson