Innate T cell recognition and development

Project Details

Researchers

Scott Reddiex, Research Assistant
Hui Fern Koay, PhD student
Michael Souter,  PhD student
Jenee Mitchell, PhD student
Catriona Nguyen-Robertson, Honours student

Funding

2015-2017 NHMRC Project Grant (CIA) APP1083885
2015 Equity Trustees grant: The William Buckland Foundation
2014-2020 Associate investigator on ARC Centre of Excellence in Advanced Molecular Imaging CE140100011
2014 University of Melbourne Early Career Research grant
2013-2017 NHMRC Early Career Research Fellowship APP1054431
2012-2016 Co-investigator on NHMRC program grant APP1013667

Research Publications

*Denotes equal first author

  1. Rahimpour A, Koay HF, Enders A, Clanchy R, Eckle SB, Meehan B, Chen Z, Whittle B, Liu L, Fairlie DP, Goodnow CC, McCluskey J, Rossjohn J, Uldrich AP, Pellicci DG, Godfrey DI. Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers. J Exp Med 2015 Jun 29;212(7): 1095-108.
  2. Birkinshaw RW*, Pellicci DG*, Cheng TY, Keller AN, Sandoval-Romero M, Gras S, de Jong A, Uldrich AP, Moody DB, Godfrey DI, Rossjohn J. αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat Immunol 2015 Mar;16(3): 258-66.
  3. Pellicci DG*, Uldrich AP*, Le Nours J, Ross F, Chabrol E, Eckle SB, de Boer R, Lim RT, McPherson K, Besra G, Howell AR, Moretta L, McCluskey J, Heemskerk MH, Gras S, Rossjohn J, Godfrey DI. The molecular bases of δ/αβ T cell-mediated antigen recognition. J Exp Med 2014 Dec 15;211(13): 2599-615.
  4. *Patel O, *Pellicci DG, *Gras S, Sandoval-Romero ML, Uldrich, AP, Clarke AJ, Le Nours J, Theodossis A, Cardell S, Gapin L, Godfrey DI, Rossjohn J. Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nat Immunol 2012 Jul 22;13(9): 857-63.
  5. *Patel O, *Pellicci DG, Uldrich AP, Sullivan LC, McKnight M, Richardson SK, Howel AR, Mallevaey T, Zhang J, Bedel R, Besra GS, Brooks AG, Kjer-Nielsen L, McCluskey J, Porcelli SA, Gapin L, Rossjohn J & Godfrey DI. Vβ2 Natural Killer T cell receptor mediated recognition of CD1d-glycolipid antigen. Proc Natl Acad Sci USA 2011 Nov 22;108(47): 19007-12.
  6. Pellicci DG*, Clarke AJ*, Patel O, Mallevaey T, Beddoe T, Le Nours J, Uldrich AP, McCluskey J, Besra GS, Steven A. Porcelli SA, Gapin L, Godfrey DI & Rossjohn J. Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nat Immunol. 2011 Jul 31;12(9): 827-33.
  7. Pellicci DG*, Patel O*, Kjer-Nielsen L*, Pang SS, Sullivan LC, Kyparissoudis K, Brooks AG, Reid HH, Gras S, Lucet IS, Koh R, Smyth MJ, Mallevaey T, Matsuda JL, Gapin L, McCluskey J, Godfrey DI, Rossjohn J. Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors. Immunity. 2009 Jul 17;31(1):47-59.

Research Group

Godfrey laboratory: The development and function of unconventional T cells



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology