Godfrey Laboratory: The Development and Function of Unconventional T Cells

Research Overview

The laboratory is interested in understanding the development and function of Innate like T cells. These include: CD1d restricted NKT cells; CD1a, CD1b and CD1c restricted T cells; MR1 restricted MAIT cells; and gamma-delta T cells.  Collectively, these cells represent a high proportion of the immune system and they have a potent ability to modulate immune responses to infections, cancer, allergens and self-tissue. There are 7 major research themes in the laboratory.

Major Research Themes:

  1. Innate-like T cell development and homeostasis
  2. Innate like T cell subsets and their functional diversity
  3. Antigen recognition by innate-like T cell receptors
  4. The role of innate-like T cells in tumour immunity
  5. The role of innate-like T cells in autoimmunity
  6. The role of innate-like T cells in allergy
  7. The role of innate-like T cells in infection.

Staff

Ms Catarina Almeida, PhD
Dr Garth Cameron, RO
Mr Marcin Ciula, RA / Lab Coordinator Mr Nicholas Gherardin, PhD
Dr Tamara Hilmenyuk, RO
Dr Darryl Johnson, RO
Ms Hui-Fern Koay, PhD
Catriona Nguyen-Robertson, Honours
Dr Daniel Pellicci, RF
Dr Fiona Ross, PhD
Dr Adam Uldrich, RF
Mr Scott Reddiex, RA
Mr Zheng Ruan, RA
Mr Shihan (Tony) Li, PhD
Mr Michael Souter, PhD
Mr John Waddington, RA

Funding

Current Grants

2012-2016: NHMRC program grant (#1013667) – Immune regulation, effector function and therapy.
Co-chief investigators: Joe Trapani, Mark Smyth, Ricky Johnstone, Dale Godfrey, Miles Prince, Michael Kershaw.
Total $2500000 p.a. DG share = $450000 p.a.

2012-2016: NHMRC Senior Principal Research Fellowship (#1020770).
Dale Godfrey.
$800K $158972 p.a.

2013-2015: A*Star-NHMRC joint grant funding Project Grant. APP1056277. Harnessing lipid-reactive immunity to combat Mycobacterium tuberculosis infection.
J Rossjohn, L Mori, D Godfrey, G DeLibero.
$330K

2013-2015:Cancer Council Victoria. J Rossjohn, D Godfrey. APP1042866. A structural and functional investigation into tumour recognition by NKT cells.
$300K

2014-2016:ARC Discovery Project. D Godfrey. APP DP140100977. Gamma delta T cells specific for glycolipid antigens.
$500K.

2014-2020:ARC Centre of Excellence in Advanced Molecular Imaging.
CIs J Whisstock, J Rossjohn, W Heath, H Quiney, K Nugent, D Godfrey, B Abbey, D Fairlie, K Gaus, A Peele, J Davey, H Chapman.
$40 million over 7 years.

Research Projects



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact Professor Dale Godfrey

Department / Centre

Microbiology and Immunology