Godfrey laboratory: The development and function of unconventional T cells
The laboratory is interested in understanding the development and function of Innate like T cells. These include: CD1d restricted NKT cells; CD1a, CD1b and CD1c restricted T cells; MR1 restricted MAIT cells; and gamma-delta T cells. Collectively, these cells represent a high proportion of the immune system and they have a potent ability to modulate immune responses to infections, cancer, allergens and self-tissue. There are 7 major research themes in the laboratory.
Major Research Themes:
- Innate-like T cell development and homeostasis
- Innate like T cell subsets and their functional diversity
- Antigen recognition by innate-like T cell receptors
- The role of innate-like T cells in tumour immunity
- The role of innate-like T cells in autoimmunity
- The role of innate-like T cells in allergy
- The role of innate-like T cells in infection.
Mr Marcin Ciula (0.6)
2012-2016: NHMRC program grant (#1013667) – Immune regulation, effector function and therapy.
Co-chief investigators: Joe Trapani, Mark Smyth, Ricky Johnstone, Dale Godfrey, Miles Prince, Michael Kershaw.
Total $2500000 p.a. DG share = $450000 p.a.
2012-2016: NHMRC Senior Principal Research Fellowship (#1020770).
$800K $158972 p.a.
2013-2015: A*Star-NHMRC joint grant funding Project Grant. APP1056277. Harnessing lipid-reactive immunity to combat Mycobacterium tuberculosis infection.
J Rossjohn, L Mori, D Godfrey, G DeLibero.
2013-2015:Cancer Council Victoria. J Rossjohn, D Godfrey. APP1042866. A structural and functional investigation into tumour recognition by NKT cells.
2014-2016:ARC Discovery Project. D Godfrey. APP DP140100977. Gamma delta T cells specific for glycolipid antigens.
2014-2020:ARC Centre of Excellence in Advanced Molecular Imaging.
CIs J Whisstock, J Rossjohn, W Heath, H Quiney, K Nugent, D Godfrey, B Abbey, D Fairlie, K Gaus, A Peele, J Davey, H Chapman.
$40 million over 7 years.
Faculty Research Themes
School Research Themes
For further information about this research, please contact Professor Dale Godfrey