Glycobiology of bacterial-host interactions
Bacterial protein glycosylation, once thought to be a rare event, is now known to to be widespread. To date multiple general bacterial glycosylation systems have been identified yet the precise functions/role in bacterial physiology are still unknown. Using mass spectrometry and proteomic based approaches, we aim to understand the function of protein glycosylation in Burkholderia species and its role in host-pathogen interactions. For example, Burkholderia cenocepecia was recently reported to possess a novel general O-linked glycosylation system required for virulence. We hypothesize that by understanding changes associated with loss of glycosylation, targets involved in pathogenesis can be identified and characterized.
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