Glycobiology of bacterial-host interactions

Project Details

Bacterial protein glycosylation, once thought to be a rare event, is now known to to be widespread. To date multiple general bacterial glycosylation systems have been identified yet the precise functions/role in bacterial physiology are still unknown. Using mass spectrometry and proteomic based approaches, we aim to understand the function of protein glycosylation in Burkholderia species and its role in host-pathogen interactions. For example, Burkholderia cenocepecia was recently reported to possess a novel general O-linked glycosylation system required for virulence. We hypothesize that by understanding changes associated with loss of glycosylation, targets involved in pathogenesis can be identified and characterized.

diagram showing ms analysis

Research Group

Hartland laboratory: Molecular basis of host-pathogen interactions

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

Unit / Centre

Hartland laboratory: Molecular basis of host-pathogen interactions