Mucosal immune responses during bacterial diarrhoea
Susceptibility to gastrointestinal pathogens is the result of complex interplay between bacterial and host factors. Attaching and effacing pathogens interfere with inflammatory and cell death signalling to overcome the host response. At the same time, multiple immune receptors attempt to activate the host response. We have discovered that cell death pathways in particular play a critical role in clearing bacterial infection and eliciting a productive immune response. We are using mice deficient in certain cell death signalling proteins and a mouse specific attaching and effacing pathogen to understand which host factors play a critical role in fighting bacterial diarrhoea.
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