Mucosal immune responses during bacterial diarrhoea

Project Details

Susceptibility to gastrointestinal pathogens is the result of complex interplay between bacterial and host factors. Attaching and effacing pathogens interfere with inflammatory and cell death signalling to overcome the host response. At the same time, multiple immune receptors attempt to activate the host response. We have discovered that cell death pathways in particular play a critical role in clearing bacterial infection and eliciting a productive immune response. We are using mice deficient in certain cell death signalling proteins and a mouse specific attaching and effacing pathogen to understand which host factors play a critical role in fighting bacterial diarrhoea.

photomicrograph showing aggregates of bacteria

Research Group

Hartland laboratory: Molecular basis of host-pathogen interactions

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

Unit / Centre

Hartland laboratory: Molecular basis of host-pathogen interactions