Immune responses in Legionnaire’s disease
Infection with L. pneumophila elicits a strong inflammatory response in the lung. This initial inflammation is important for subsequent recruitment and activation of immune responses necessary to control and clear the infection. We have discovered that certain subsets of dendritic cells (DC) play a role in limiting bacterial replication in the lung. The aim of this work is to understand the mechanisms by which DC contribute to resistance to infection with Legionella and other bacterial pathogens. This work will not only contribute to our understanding of the pathogenesis of Legionnaire's disease but will also provide novel information on the functions of DC in the lung.
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