Translocated Dot/Icm effectors of Legionella
Legionella pneumophila is an environmental organism and the major cause of Legionnaire's Disease, an acute form of pneumonia. The Legionella genome encodes around 300 effector proteins that are translocated into eukaryotic cells by the Dot/Icm type IV secretion system (T4SS). The function of the vast majority of effectors is unknown. Many effectors share similarity with eukaryotic proteins and these are predicted to allow L. pneumophila to manipulate host cell processes by functional mimicry of eukaryotic proteins. Our aim is to identify the biochemical function of Dot/Icm effector proteins, which will allow us to understand the molecular mechanisms by which Legionella replicates in the human lung and causes disease.
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