Translocated Type III secretion system effectors of bacterial pathogens

Project Details

Many bacterial pathogens have the ability to transport virulence proteins, termed effector proteins, into host cells via a specialized protein secretion system called a type III secretion system (T3SS). We work on a range of T3SS effectors from bacterial enteric pathogens interfere with host innate immune signalling pathways and block inflammation and cell death. The aim of our research is to identify the biochemical activity of T3SS effector proteins and understand their influence on host cell function, inflammatory signalling and the immune response.

transmission electron micrograph of microvilli

Research Group

Hartland laboratory: Molecular basis of host-pathogen interactions

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology

Unit / Centre

Hartland laboratory: Molecular basis of host-pathogen interactions