Translocated Type III secretion system effectors of bacterial pathogens
Many bacterial pathogens have the ability to transport virulence proteins, termed effector proteins, into host cells via a specialized protein secretion system called a type III secretion system (T3SS). We work on a range of T3SS effectors from bacterial enteric pathogens interfere with host innate immune signalling pathways and block inflammation and cell death. The aim of our research is to identify the biochemical activity of T3SS effector proteins and understand their influence on host cell function, inflammatory signalling and the immune response.
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