Autophagy and Norovirus replication

Project Details

We are also interested in the role autophagy plays in MNV-1 replication. Autophagy is a cellular mechanism used to recycle proteins and degrade pathogens as a method of prolonging cell life. We have since discovered that MNV-1 infection induces autophagy but does not utilize the autophagosomal membranes to facilitate replication. Various techniques have been used in this project including; immunofluorescence, western blotting, qPCR, plaque assays and live cell imaging. Further analyses will examine the effects of autophagy inducing and inhibiting compounds on MNV-1 replication and what implications these results will reveal about how MNV-1 is able to manipulate cells.

Researchers

Ms Tanya O'Donnell (PhD student)

Collaborators

Justine Mintern (University of Melbourne) and Skip Virgin (Washington University School of Medicine, USA)

Research Group

Mackenzie laboratory: Intracellular virus replication and innate immunity



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology