The role of innate immune cells in protection and pathology during influenza virus infection
Infection of respiratory epithelium and airway macrophages/DC results in the release of a range of chemokines and cytokines, which in turn leads to the recruitment of innate inflammatory cells such as neutrophils and natural killer cells to the airways. We are interested in understanding factors governing the recruitment, activation and role of innate inflammatory cells during influenza infections. While innate immune cells are generally associated with resolution of infection, dysregulated recruitment and activation of innate cells can contribute to pulmonary pathology and disease.
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