Cell surface receptors for attachment and entry of influenza virus into cells of the innate immune system
Airway macrophages and dendritic cells (DC) are important components of innate host defense and play a critical role in limiting the severity of influenza infection. Detailed information regarding the mechanisms by which macrophages and DC recognize influenza virus for attachment, uptake and destruction are lacking. Our group has recently identified specific receptors involved in influenza virus infection of macrophages and DC. We now aim to investigate virus-encoded and host-encoded determinants that modulate efficiency of virus binding and infection. These studies will provide novel information regarding how influenza virus is first recognized by cells of the innate immune system as well as insight into why virulent strains circumvent uptake and destruction by macrophages and DC.
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