Brown laboratory: Immunology; virology; vaccinology

Research Overview

All research currently performed by the team involves investigation and control of influenza.

Immunology

  • Interaction of influenza virus and dendritic cells
  • Manipulation of immunogen composition to perturb activation pathways in dendritic cells
  • Passive antibody transfer for prevention and control of influenza (with Immuron Ltd)
  • The role of costimulation in the priming of effector and memory CD8+ T cells against influenza (with Andrew Lew, Yifan Zhan and Shirley Seah, WEHI)

Virology

  • The role of the influenza protein PB1-F2 in the pathogenesis of influenza
  • Location of the site of binding of an innate inhibitor of influenza to the virus particle
  • The role of amino acids within the cytoplasmic tail of the viral hemagglutinin in budding and particle formation
  • Progression of H5N1 and seasonal influenza within and external to the respiratory tract in ferrets (with Deborah Middleton, AAHL)
  • Factors governing animal-to-animal transmission of different influenza virus strains
  • Electron microscopic evaluation of the mechanism of action of anti-influenza drugs (with Biota)
  • Factors responsible for the acquisition of high pathogenicity phenotype of H5N1 in mammals (with Deborah Middleton and Sandra Sapats, AAHL, and Steve Rockman, CSL Ltd)

Vaccinology

  • Effect of combining a CTL-inducing component with the seasonal split virus vaccine on vaccine outcome (with David Jackson)
  • Identifying the effect of gene constellation of vaccine seed viruses of vaccine yield (with Steve Rockman, CSL Ltd)
  • Evaluation of immunogenicity and protective efficacy of  H5N1 and swine-origin H1N1 vaccines in ferrets (with AAHL, CSL Ltd and WHO Centre for Influenza Reference and Research)
  • Evaluation of nanopatch technology for the delivery of influenza vaccines (with Mark Kendall and colleagues, UQ)
  • Evaluation of plant-derived influenza hemagglutinin as a vaccine candidate (with Diane Webster and colleagues, Monash University)

Staff

Mrs Emily Fairmaid (Milne), RA
Mr Charley Mackenzie-Kludas, RA
Miss Sanja Trifkovic, PhD
Dr Rob Allen, PhD
Miss Patricia Lee, PhD
Dr Brad Gilbertson, SRO
Dr Julie McAuley, SRO

Research Projects



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact Professor Lorena (Lori) Brown

Department / Centre

Microbiology and Immunology