NKT cells, MAIT cells and HIV
NKT cells are a small but very important lymphocyte population in blood that possess potent antiviral and antitumor activities. In collaboration with Dr Godfrey and colleagues, we recently showed NKT cells are depleted during SIV and SHIV infection of monkeys (Fernandez et al, Journal of Virology, 2009). We are now devising strategies to enhance the biologic utility of NKT cells in fighting HIV. We are also starting to study an interesting population of cells called Mucosal-associated Invariant T cells (MAIT cells).
Figure 1: NKT cell population in Macaca Nemestrina blood
Dr Stephen Kent, Prof Dale Godfrey, Ms Caroline Fernandez, Ms Thakshila Amarasena.
NHMRC Program Grant #510448
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