NKT Cells, MAIT Cells and HIV

Project Details

NKT cells are a small but very important lymphocyte population in blood that possess potent antiviral and antitumor activities. In collaboration with Dr Godfrey and colleagues, we recently showed NKT cells are depleted during SIV and SHIV infection of monkeys (Fernandez et al, Journal of Virology, 2009). We are now devising strategies to enhance the biologic utility of NKT cells in fighting HIV. We are also starting to study an interesting population of cells called Mucosal-associated Invariant T cells (MAIT cells).

NKT cell population in Macaca Nemestrina blood

Figure 1: NKT cell population in Macaca Nemestrina blood

Researchers

Dr Stephen Kent, Prof Dale Godfrey, Ms Caroline Fernandez, Ms Thakshila Amarasena.

Funding

NHMRC Program Grant #510448

Research Group

Kent laboratory: HIV vaccines; immune responses to HIV-1; immunotherapy



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology