Influenza–specific ADCC: Role in a universal flu vaccine?
Influenza mutates regularly to avoid neutralizing antibodies and immune responses that target more conserved areas are needed to combat new flu pandemics. Influenza ADCC has been a neglected area of research in recent decades. We adapted and refined our HIV ADCC assays to study Influenza. We found there is a remarkable degree of cross-reactivity in Influenza ADCC immunity. We recently found that influenza ADCC can play a role in reducing the severity of the 2009 Swine Flu epidemic in both humans and monkeys . The work opens up a whole new field of Flu immunity. We are now studying how Flu-specific ADCC can be induced by vaccination and lead to protective immunity.
Mr Sinth Jegaskanda, Dr Matt Parsons with collaborators Pat Reading, Andrew Brooks, the WHO Flu center and the University of Wisconsin.
NHMRC project grant #1042634
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