Imaging effector and memory T cell responses in the skin following Herpes Simplex Virus-1 infection

Project Details

Our project entails investigation of the cellular interactions between immune cells in the secondary lymphoid organs following peripheral viral infection. By employing a cutaneous herpes simplex virus infection model, where the antigen-presenting cells from the skin are vital to the induction of immunity, and combined with state-of-the-art multiphoton microscopy as well as transgenic mouse models, we are now able to visualise the dynamic interaction in vivo between antigen-presenting cells and helper CD4 as well as killer CD8 T cells in the skin-draining lymph node. This project attempts to further our understanding of the priming of adaptive immune system crucial for developing vaccination and therapeutic strategies.

Movie

Dynamic interactions between helper CD4 T cells (green) and migratory dendritic cells (red) in the skin-draining lymph node during the priming phase of T cell response after skin HSV-1 challenge.

NB: this is a collaborative project with the Mueller group.

Researchers

Jyh Liang Hor
Dr Scott Mueller

Research Group

Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Cellular Imaging & Structural Biology, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology