Dendritic cell maturation following different microbial stimulation

Project Details

The aim of my project is to understand the mechanisms of DC maturation following activation with different microbial stimuli and the differential requirements for CD4+ T cell help in the process of DC priming. More precisely, I am interested in elucidating how the combination and integration of these differential signals shapes the secretion of cytokines by DC necessary to induce an efficient CTL response upon infection.

diagram showing DC maturation

NB: this is a collaborative project with the Bedoui group.

Researchers

Marie Greyer
Dr Sammy Bedoui

Research Group

Heath laboratory: CD8 T lymphocytes, dendritic cells, self tolerance and immunity



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease, Cellular Imaging & Structural Biology



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology