Structural Determinants of CTL TCR Diversity and PMHC Recognition

Project Details

A hallmark of many T cell is the preferred usage of particular T cell receptor combinations. Recent data has suggested a link between TCR diversity and outcome to infection. Given TCR bias is such a characteristic of immunity, we are using a combination of structural biology, retroviral transduction of known influenza-specific TCRs and single cell analysis of TCR repertoire diversity to examine the structural requirements for TCR peptide-MHC recognition, how this influences antigen-specific TCR diversity and how these factors impact the quality of immunity to infection.

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology