Analysis of Factors That Determine Immunodominance Hiearchies

Project Details

Despite the many potential peptide-MHC combinations that could be recognised by the immune system, T cell responses are generated only to a few of them. Moreover, the size of the T cell response to pathogen derived peptide-MHC complexes falls into a reproducible hierarchy. We utilise a combination of influenza reverse genetics, naïve T cell precursor detection and multi parameter flow cytometry to understand factors that influence the magnitude of T cell responses to acute infection.

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology