Acquisition, Epigenetic and Transcriptional Regulation of CTL Gene Expression Within Both Effector and Memory CTL

Project Details

Upon activation, naïve T cells undergo a program of proliferation and acquisition of lineage specific functions. Importantly, the factors that regulate acquisition and maintenance of T cell effector function. Furthermore, we are particularly interested in how T cell effector functions acquired during initial activation are maintained into memory. We are using a combination of a single cell RT-PCR technique, identifying novel transcriptional and epigenetic pathways, and over-expression analysis of key regulators to map key events that enable lineage specific T cell function and the establishment of memory. Such analysis will tell us if the molecular mechanisms regulating transcriptional control of T cell effector function are unique and/or shared among key effector genes. This will lead to identification of key immune correlates of protective immunity and will contribute to improvement of immunotherapies for both infectious and autoimmune disease.

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Microbiology and Immunology