Stinear laboratory: Bacterial pathogenomics

Research Overview

The Stinear Laboratory uses genomics and molecular biology to understand how certain groups of bacteria evolve and cause disease in humans. We then try and translate that knowledge into improving human health. For example, we have used our findings to guide the use of antibiotics for improved treatment of infections and to develop better diagnostic methods that can more rapidly and accurately detect infections.  We focus our research efforts on the bacterial pathogens Mycobacterium ulcerans, Mycobacterium marinum, Mycobacterium tuberculosis, Staphylococcus aureus and Enterococcus faecium. Our laboratory works in close partnership with the Infectious Diseases and Microbiology Departments at Austin Health and the World Health Organization Collaborating Centre for Mycobacterium ulcerans at the Victorian Infectious Diseases Reference Laboratory.

Some useful links

For more information regarding polyketide synthases visit the site of Prof Peter Leadlay

Prof Paul Johnson and the Victorian Government provide general information on Mycobacterium ulcerans and the disease it causes.

The Stop Buruli Initiative is a program of the UBS-Optimus Foundation to address key research priorities for Buruli ulcer.

BuruliList is a server hosted by the Institut Pasteur with the complete M. ulcerans genome sequence.

Burulivac is an initiative of the European Union to try and develop vaccines against Buruli ulcer.

Staff

Mr Andrew Abuultjens, PhD
Mr Wei Gao, PhD
Dr Romain Guerillot, Post Doc
Dr Kyra Chua, Post Doc
Miss Margaret Lam, PhD
Ms Kirstie Mangas, PhD
Dr Ian Monk, Post Doc
Ms Jessica Porter, RA
Dr Jason Kwong, PhD
Dr Jean Lee, PhDDr Sacha Pidot, Post Doc
Sarah Baines, PhD
Megan Pidot, RA
Stefano Giulleri, Visiting Scientist
Norelle Sherry, PhD

Collaborators

Professor Benjamin Howden, Department of Infectious Diseases, Austin Health
Dr Torsten Seemann, Victorian Bioinformatics Consortium, Monash University
Prof Paul Johnson, Department of Infectious Diseases, Austin Health
Dr Grant Jenkin, Department of Infectious Diseases, Monash Medical Centre, Monash University
Dr Kellie Tuck, School of Chemistry, Monash University
Dr Kumar Visanathan, Centre for Inflammatory Diseases at Monash Medical Centre
Prof Gerd Pluschke, Swiss Tropical Public Health Institute in Basel
Dr Janet Fyfe, M. ulcerans WHO Collaborating Centre, Victorian Infectious Diseases Reference Laboratory
Prof Peter Leadlay, Department of Biochemistry, University of Cambridge, UK.
Dr Hui Hong, Department of Chemistry, University of Cambridge, UK.
Dr Caroline Demangel, PMI, Institut Pasteur, Paris
Assoc Prof. Roland Brosch, PMI, Institut Pasteur, Paris
Dr Laurent Marsollier, Groupe d'étude des interactions hôtes-parasites, Université d'Angers, France
Dr John R Wallace, Department of Biology, Millersville University, PA, USA.
Prof Jacques Schrenzel, Genomic Reseach Laboratory, University of Geneva Hospitals, Switzwerland
Dr Patrice Francois, Genomic Reseach Laboratory, University of Geneva Hospitals, Switzwerland
Prof Catherine Bennett, School of Health & Social Development, Deakin University

Funding

Research Projects



Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Systems Biology



Key Contact

For further information about this research, please contact Professor Tim Stinear

Department / Centre

Microbiology and Immunology