Memory T cell responses in the lung during virus infection

Project Details

Many viruses enter the body by inhalation and initiate their replication cycle within the lung. The early stage of infection, while the virus is confined to the lung, provides the ideal window of opportunity for an effective immune response. Tissue-resident memory (Trm) CD8 T cells, reside in the lung and are ideally situated to act during this window and stall the infection. Strategies that generate Trm within the lung hold significant therapeutic potential. We are currently investigating Trm within the lung, factors important in their differentiation and longevity and novel ways to generate them.