Transcriptional regulation of intestinal organoid differentiation
|Associate Professor Gary Himefirstname.lastname@example.org||+ 61 3 834 45796|
Intestinal organoid cultures recapitulate the stem cell niche in an easily accessible system. Stem cells renew the intestinal epithelium and produce all of the differentiated cells normally found in an in vivo epithelium. We are using loss of function and overexpression models to examine how EMT transcription factors regulate stem cell behaviour.
Franca Casagranda, Research Assistant,
Associate Professor Helen Abud, Monash University Biomedicine Discovery Institute
This research project is available to PhD, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
- Horvay K, Jarde T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR*, Abud HE*. Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO Journal 2015; 34(10): 1319-35.
*joint senior authors,
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For further information about this research, please contact the research group leader.