Transcriptional regulation of intestinal organoid differentiation

  • Project Leader

    Associate Professor Gary Hime
    T: + 61 3 834 45796
    E: g.hime@unimelb.edu.au
    Location: Level 06, Room W513A, Medical Building, Parkville

Project Details

Intestinal organoid cultures recapitulate the stem cell niche in an easily accessible system. Stem cells renew the intestinal epithelium and produce all of the differentiated cells normally found in an in vivo epithelium. We are using loss of function and overexpression models to examine how EMT transcription factors regulate stem cell behaviour.

Researchers

Franca Casagranda, Research Assistant,

Collaborators

Associate Professor Helen Abud, Monash University Biomedicine Discovery Institute

Research Opportunities

This research project is available to PhD, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

  • Horvay K, Jarde T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR*, Abud HE*.  Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO Journal 2015; 34(10): 1319-35.
    *joint senior authors,

Research Group

Hime laboratory: Stem cell genetics



Faculty Research Themes

Cancer

School Research Themes

Cancer in Biomedicine, Cell Signalling, Stem Cells



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience

Unit / Centre

Hime laboratory: Stem cell genetics