EMT regulators in intestinal and germline stem cells

Project Details

We have shown that members of the Snail family of transcriptional repressors are required in diverse stem cell populations. This role has been conserved through evolution of animals as Snail family members can be found in stem cells from Drosophila to mouse.  This project involves using genetically modified Drosophila or mouse strains to identify how these proteins regulate stem cell numbers and control the production of differentiated progeny cells.

Researchers

Franca Casagranda, Research Assistant

Nicole Dominado, PhD student

Elena Savva, MSc student

Yoshana Fonseka, Honours student

Collaborators

Associate Professor Helen Abud, Monash University Biomedicine Discovery Institute

Professor D Leanne Jones, University of California at Los Angeles

Research Opportunities

This research project is available to PhD, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

  • Horvay K, Jarde T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR*, Abud HE*. Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO Journal 2015; 34(10): 1319-35.
    *joint senior authors
  • Voog J, Sandall SL, Hime GR, Resende LP, Loza-Coll M, Aslanian A, Yates JR 3rd, Hunter T, Fuller MT, Jones DL. ( Escargot restricts niche cell to stem cell conversion in the Drosophila testis. Cell Reports 2014; 7(3): 722-34.
  • Horvay K, Casagranda F, Gany A, Hime GR, Abud HE. Wnt Signaling Regulates Snai1 Expression and Cellular Localization in the Mouse Intestinal Epithelial Stem Cell Niche. Stem Cells Dev 2011; 20(4): 737-745.

Research Group

Hime laboratory: Stem cell genetics



Faculty Research Themes

Cancer, Child Health

School Research Themes

Cancer in Biomedicine, Cell Signalling, Stem Cells



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience

Unit / Centre

Hime laboratory: Stem cell genetics