Cellular trafficking and male fertility

Project Details

Development of functional sperm requires control not only of gene expression but also correct regulation of protein and lipid membrane trafficking. Processes as diverse as stem cell differentiation, specialised germ cell cytokinesis and development of elongated spermatozoa all have specific requirements for protein localisation and membrane re-arrangement. We are examining the roles of nuclear importation and vesicular trafficking in sperm development.

Researchers

Nicole Siddall, Postdoctoral Researcher

Franca Casagranda, Research Assistant

James Heaney, PhD student

John Qi, MSc student

Caitlin van Ree, Honours student

Collaborators

Professor Kate Loveland, Hudson Institute of Medical Research

Professor Julie Brill, The Hospital for Sick Kids, Toronto, Canada

Research Opportunities

This research project is available to PhD, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

  • Brill, JA, Hime, GR, Scharer-Schuksz, M, Fuller, MT.  () A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Development 2000; 127: 3855-3864.

Research Group

Hime laboratory: Stem cell genetics



Faculty Research Themes

Child Health

School Research Themes

Cell Signalling, Stem Cells



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience

Unit / Centre

Hime laboratory: Stem cell genetics