Analysing the role of transcriptional repressors in Drosophila and mouse stem cells
We have shown that members of the Snail family of transcriptional repressors are required in diverse stem cell populations. This role has been conserved through evolution of animals as Snail family members can be found in stem cells from Drosophila to mouse. This project involves using genetically modified Drosophila or mouse strains combined with RT-PCR, microarrays and immunostudies to identify what factors are being repressed by Snail family proteins in stem cells.
A rosette of germline stem cells (expressing the Snail family zinc finger protein Escargot, green) can be observed surrounding the somatic stem cell niche in the Drosophila testis.
Associate Professor Gary Hime
Dr Helen Abud, Monash University
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