Analysing the role of transcriptional repressors in Drosophila and mouse stem cells

Project Details

We have shown that members of the Snail family of transcriptional repressors are required in diverse stem cell populations. This role has been conserved through evolution of animals as Snail family members can be found in stem cells from Drosophila to mouse. This project involves using genetically modified Drosophila or mouse strains combined with RT-PCR, microarrays and immunostudies to identify what factors are being repressed by Snail family proteins in stem cells.


A rosette of germline stem cells (expressing the Snail family zinc finger protein Escargot, green) can be observed surrounding the somatic stem cell niche in the Drosophila testis.

Researchers

Associate Professor Gary Hime

Collaborators

Dr Helen Abud, Monash University

Research Group

Hime laboratory: Stem cell genetics



Faculty Research Themes

Cancer

School Research Themes

Cancer in Biomedicine, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience