Analysing genetic roles of RNA-binding proteins and alternative splicing in Drosophila stem cells

Project Details

We have identified that the RNA-binding proteins, Musashi, Enhancer of Rudimentary and Held-Out-Wings (HOW) are required to either prevent stem cells from differentiating in the stem cell niche or are required to regulate the cell cycle of stem cells. This project utilises a variety of genetic, molecular biology and immunostaining techniques to identify the roles of these proteins in different stem cell populations.

Researchers

Nicole Siddall, Postdoctoral Researcher

Franca Casagranda, Research Assistant

Farnaz Shapouri, PhD student,

Shaghyegh Saeidi, PhD student

John Qi, MSc student

Collaborators

Professor Eileen McLaughlin, University of Auckland

Research Opportunities

This research project is available to PhD, Honours students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Publications

  • Monk AC, Siddall N, Volk T, Fraser BA, Quinn LM, McLaughlin EA, Hime GR.  The RNA-binding protein HOW is required for stem cell maintenance in the testis and for the onset of transit amplifying divisions. Cell Stem Cell 2010; 6(4): 348-60.
  • Siddall NA, McLaughlin EA, Marriner NL, Hime GR.  The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity. Proc Natl Acad Sci USA 2006; 103: 8402-8407.

Research Group

Hime laboratory: Stem cell genetics



Faculty Research Themes

Cancer, Child Health

School Research Themes

Cancer in Biomedicine, Cell Signalling, Stem Cells



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience

Unit / Centre

Hime laboratory: Stem cell genetics