How does inflammation affect the activity of primary afferent neurons that innervate bone?
Inflammation heightens the responsiveness (reduces threshold to activation and increases discharge frequency) of peripheral sensory neurons that innervate skin, joints and viscera. In this project, we will examine how inflammatory bone pain and peripheral application of algesic substances affect the activity of peripheral axon terminals of bone afferent neurons in vivo. Students can expect to gain experience in working with an in vivo electrophysiological bone-nerve preparation, small animal handling, behavioural testing, anaesthesia, surgery and dissection.
Jenny Thai, Research assistant
Sara Nencini, PhD student
Abdulhakeem Alamri, PhD student
Associate Professor James Brock
Dr Michael Barrington
Associate Professor Louise Purton
Faculty Research Themes
School Research Themes
For further information about this research, please contact the research group leader.