How does inflammation affect the activity of primary afferent neurons that innervate bone?

Project Details

Inflammation heightens the responsiveness (reduces threshold to activation and increases discharge frequency) of peripheral sensory neurons that innervate skin, joints and viscera. In this project, we will examine how inflammatory bone pain and peripheral application of algesic substances affect the activity of peripheral axon terminals of bone afferent neurons in vivo. Students can expect to gain experience in working with an in vivo electrophysiological bone-nerve preparation, small animal handling, behavioural testing, anaesthesia, surgery and dissection.


Jenny Thai, Research assistant
Sara Nencini, PhD student
Abdulhakeem Alamri, PhD student


Associate Professor James Brock
Dr Michael Barrington
Associate Professor Louise Purton

Research Group

Ivanusic laboratory: Pain and sensory mechanisms

Faculty Research Themes


School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease, Systems Biology, Therapeutics & Translation

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience

Unit / Centre

Ivanusic laboratory: Pain and sensory mechanisms