The role of Egr genes in retinal remodelling

Project Details

Following loss of the photoreceptors in retinal degenerations, there are marked structural changes that occur in the retina, involving glial scar formation, aberrant neuronal migration, neurite extension and synaptogenesis as well as neuronal death.  However, nothing is known about the molecular mechanisms that initiate or mediate the morphological changes associated with retinal remodelling.  Using microarrays we have identified two transcription factors (Egr1, Egr3) that are dramatically up-regulated during this remodelling process. The aim of this project is to examine the expression of these transcription factors during the period of retinal remodelling and to identify their downstream target genes.

Techniques will include management of mouse colonies, collection of retinae for immunohistochemistry, western blotting, in situ hybridisation and chromatin immunoprecipitation. 

(collaboration with Fletcher Lab)

Researchers

A/Prof Robb de Iongh

Research Group

De Iongh laboratory: Ocular development laboratory



Faculty Research Themes

Neuroscience

School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience