Role of Sez-6 in cocaine self‐administration and extinction
Pilot studies from our laboratory indicate that conditional deletion of the sez-6 gene alters cocaine-induced reinstatement of conditioned place preference in mice, a model for relapse in human drug addiction. This project will test the sez-6conditional knockout mice in an operant conditioning paradigm involving intravenous self-administration of cocaine, extinction of cocaine-seeking and relapse to cocaine-seeking after extinction. Effects on neuron morphology in brain "reward centres" will be examined using immunohistochemistry and Golgi-Cox tracing.
- Dr Jenny Gunnersen
- Professor Andrew Lawrence
This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.
Faculty Research Themes
School Research Themes
For further information about this research, please contact the research group leader.