Role of Sez-6 in cocaine self‐administration and extinction

Project Details

Pilot studies from our laboratory indicate that conditional deletion of the sez-6 gene alters cocaine-induced reinstatement of conditioned place preference in mice, a model for relapse in human drug addiction. This project will test the sez-6conditional knockout mice in an operant conditioning paradigm involving intravenous self-administration of cocaine, extinction of cocaine-seeking and relapse to cocaine-seeking after extinction. Effects on neuron morphology in brain "reward centres" will be examined using immunohistochemistry and Golgi-Cox tracing.


  • Dr Jenny Gunnersen
  • Professor Andrew Lawrence

Research Opportunities

This research project is available to PhD students to join as part of their thesis.
Please contact the Research Group Leader to discuss your options.

Research Group

Gunnersen laboratory: Neuron development and plasticity

Faculty Research Themes


School Research Themes

Biomedical Neuroscience, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience